What happens to a differentiating stem cell's gene expression profile when transcription factors activate lineage-specific genes?

💡 Explanation

Stem cell differentiation involves a carefully orchestrated shift in gene expression. Activation of lineage-specific genes represses the genes maintaining pluripotency via epigenetic mechanisms, because differentiation is mutually exclusive with pluripotency; therefore, the expression of pluripotency genes decreases, rather than continues or remains unchanged.

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