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Which byproduct accumulation decelerates enzyme mediated metabolic reactions?

A)Increased product feedback inhibition
B)Reduced catalyst active site exposure
C)Elevated substrate diffusion resistance
D)Depleted enzyme Michaelis constant affinity

💡 Explanation

Product buildup increases feedback inhibition, downregulating the reaction because the enzyme's active site binds the product rather than the substrate. Therefore, production rate slows; it's active site affinity rather than a diffusion bottleneck determining the outcome.

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