Which constraint occurs during polypeptide folding if hydrophobic residues cannot properly coalesce, impacting hydrogen bonds?

A)Impaired protein tertiary structure✓

B)Increased alpha helix formation

C)Accelerated disulfide bridge crosslinking

D)Enhanced hydrophilic residue exposure

💡 Explanation

Improper interactions prevent stabilizing hydrogen bonds, leading to impaired structures, because aggregation drives hydrophobic collapse. Without this collapse, key structure-stabilizing hydrogen bonds cannot form; therefore, tertiary structure integrity diminishes rather than other secondary structure enhancements.

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Which constraint occurs during polypeptide folding if hydrophobic residues cannot properly coalesce, impacting hydrogen bonds?

💡 Explanation

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