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Human Body & Health

Which event impairs function when certain toxins hyperstimulate synapses?

A)Excitotoxicity and neuronal cell death
B)Increased action potential propagation speed
C)Enhanced neurotransmitter reuptake efficiency
D)Reduced synaptic vesicle replenishment rate

💡 Explanation

Excitotoxicity occurs because excessive synaptic stimulation triggers uncontrolled calcium influx through the NMDA receptors. This overwhelms the cell, disrupting its normal function and causing cell death, therefore excitotoxicity produces neurodegeneration, rather than simply vesicle depletion.

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