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Which mechanism disrupts protein folding fidelity during aggregation?

A)Hydrophobic intermolecular interactions
B)Electrostatic molecular repulsions
C)Hydrogen bond saturation
D)Orbital hybridization interference

💡 Explanation

Hydrophobic patches drive aberrant aggregation because hydrophobic intermolecular interactions cause non-native protein associations, resulting in misfolding; therefore, aggregation occurs, rather than proper folding mediated by chaperone proteins or solvation.

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