Which mechanism increases metabolic heat during prolonged shivering in mammals?

💡 Explanation

During prolonged shivering, activation of uncoupling protein 1 (UCP1) in mitochondria occurs because proton gradients dissipate, leading to heat generation instead of ATP production, massively increasing metabolic rate. Therefore brown fat UCP1 activation specifically causes thermogenesis, rather than vasodilation, reduced TSH, or liver glycogenolysis, which operate through separate pathways.

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