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Which mechanism inhibits complete oxidation if electron-withdrawing groups block enzyme active sites?

A)Steric hindrance by bulky substituents
B)Inductive effect alters transition states
C)Quantum tunneling is exponentially suppressed
D)Electron delocalization stabilizes carbanions

💡 Explanation

Inhibiting oxidation occurs via the inductive effect because electron-withdrawing groups alter intermediate stability, raising the activation energy needed for substrate electron transfer; therefore, incomplete oxidation occurs rather than full conversion if the transition state destabilizes.

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