Which mechanism limits the effectiveness of a molecule used in targeted alpha therapy (TAT) when delivered intravenously?

💡 Explanation

When alpha particles emitted from the radionuclide interact with water molecules near targeting moieties, radiolytic decomposition occurs due to water radiolysis forming free radicals, disrupting the molecule's binding affinity to cancer cells. Therefore radiolytic decomposition limits effectiveness, rather than cellular uptake, nuclear export, or off-target accumulation which depend on different mechanisms.

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