Which mechanism limits the effectiveness of certain polymers as drug-delivery vehicles at high molar mass?

💡 Explanation

When polymer molar mass increases, the drug's slower movement through tissues occurs because the diffusion coefficient decreases with increasing molecule size due to frictional drag, compromising penetration. Therefore, slower diffusion limits effectiveness, rather than faster entanglement reduction, degradation changes, or preciipitation, which require altered molecular interactions.

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