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Which outcome decreases catalytic activity when enzyme orbitals distort?

A)Substrate binding weakens significantly
B)Active site residue stability boosts
C)Product release energy decreases
D)Enzyme refolding becomes thermodynamically neutral

💡 Explanation

Decreased catalytic activity results in substrate binding affinity decreasing because orbital distortion prevents optimal substrate-enzyme interactions, weakening the transition state stabilization, therefore weakening substrate binding rather than altering residue stability because other factors do not directly govern residue interactions.

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