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← ScienceWhich outcome occurs when a misfolded protein evades proteasomal degradation?
A)Enhanced rate of endocytosis occurs
B)Molecular chaperone refolding is accelerated
C)Amyloid plaque aggregate accumulates extracellularly✓
D)Intracellular ribosome production is activated
💡 Explanation
Amyloid plaque forms, triggered by proteasome failure. Protein aggregation results from a disruption in proteostasis via nucleation; because the ubiquitin-proteasome system fails, the misfolded protein aggregates extracellularly. Aggregation rather than endocytosis occurs because proteasomes recycle misfolded intracellular molecules.
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