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← ScienceWhich outcome occurs when a pharmaceutical drug molecule's binding affinity decreases?
A)Reduced therapeutic biological effect✓
B)Higher drug metabolic stability
C)Enhanced target receptor selectivity
D)Increased drug bioavailability fraction
💡 Explanation
Decreasing binding reduces the opportunity for molecular interactions with the receptor, therefore the intended therapeutic biological effect is reduced, because the drug’s efficacy depends on strong molecular affinity rather than enhanced alternative factors like stability.
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