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← ScienceWhich outcome occurs when a protein encounters an energy barrier during configuration sampling?
A)Accelerated protein folding pathway
B)Conformational changes get kinetically trapped✓
C)Increased rate of spontaneous aggregation
D)Global minimization becomes computationally straightforward
💡 Explanation
Conformational changes get kinetically trapped, because the protein lacks sufficient energy to overcome the energetic barrier via a mechanism influencing transition state theory, therefore halting sampling rather than other options involving spontaneous change which demand more energy.
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