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Which outcome occurs when a protein encounters an energy barrier during configuration sampling?

A)Accelerated protein folding pathway
B)Conformational changes get kinetically trapped
C)Increased rate of spontaneous aggregation
D)Global minimization becomes computationally straightforward

💡 Explanation

Conformational changes get kinetically trapped, because the protein lacks sufficient energy to overcome the energetic barrier via a mechanism influencing transition state theory, therefore halting sampling rather than other options involving spontaneous change which demand more energy.

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