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← ScienceWhich outcome occurs when an enzyme's active site distorts?
A)Substrate-induced strain energy diminishes✓
B)Reaction's rate determining step changes
C)Transition state stabilization increases
D)Microenvironmental pH dramatically shifts
💡 Explanation
Substrate-induced strain energy diminishes because induced fit relies on destabilizing the substrate structure via the enzyme mechanically twisting it into higher energy conformation, lowering total activation energy. Therefore, weakened strain lowers efficiency rather than rate enhancements, because the reaction faces a larger energy barrier.
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