Which outcome occurs when beta-adrenergic receptors downregulate in cardiomyocytes?

💡 Explanation

Reduced receptor density causes desensitization. Beta-adrenergic receptor downregulation decreases the heart's responsiveness to catecholamines, because the number of available receptors reduces adrenergic signaling. Therefore, contractility falls; rather than cardiac output increasing, as it could with more receptors present.

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