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← ScienceWhich outcome occurs when disulfide bonds fail during protein refolding?
A)Accumulation of misfolded protein aggregates✓
B)Increased protein thermal conformational stability
C)Enhanced protein secretion efficiency system
D)Decreased enzymatic activity of peptide
💡 Explanation
Protein misfolding results from incorrect disulfide bond formation during refolding, because it hinders proper three-dimensional structure by changing the protein–protein interactions. Therefore, aggregation occurs, rather than stability, secretion, enzymatic activity because of disrupted hydrogen bonds.
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