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← ScienceWhich outcome occurs when excessive non-competitive inhibitor binds an enzyme?
A)Reaction rate experiences a Vmax decrease✓
B)Reaction achieves thermodynamically unstable equilibrium
C)Substrate affinity displays an apparent increase
D)Inhibition reverses upon substrate addition
💡 Explanation
Enzyme activity decreases because *conformational change* reduces its catalytic efficiency regardless of substrate concentration, thereby decreasing the Vmax; therefore the rate decreases, rather than changing substrate affinity which occurs in competitive inhibition.
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