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Human Body & Health

Which outcome results when a granulosa cell loses its ability to express aromatase during the mid-follicular phase?

A)Decreased estradiol synthesis locally
B)Enhanced androgen receptor sensitivity
C)Increased luteinizing hormone binding
D)Suppressed follicle-stimulating hormone secretion

💡 Explanation

Reduced aromatase hinders the conversion of androgens to estrogens (estradiol) in granulosa cells due to impaired steroidogenesis; therefore, local estradiol concentrations decrease rather than other hormonal cascades being directly affected; this impacts follicle maturation.

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