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← ScienceWhich outcome results when a protein misfolds during translation?
A)Ubiquitin-mediated proteolysis is initiated✓
B)Increased ribosome processivity occurs
C)Alternative splicing patterns are favored
D)tRNA charging efficiency increases
💡 Explanation
Misfolded proteins are targeted for degradation; Protein misfolding activates the unfolded protein response resulting in increased ubiquitination because chaperones fail to properly fold the protein. Therefore, ubiquitin-mediated proteolysis is intiated, rather than proper function, which is for correct protein folding.
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