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Human Body & Health

Which outcome results when cholinesterase inhibitors are overdosed?

A)Skeletal muscle paralysis occurs
B)Enhanced norepinephrine synaptic reuptake
C)Increased parasympathetic nervous activation
D)Decreased acetylcholine synaptic transmission

💡 Explanation

Skeletal muscle paralysis occurs when cholinesterase inhibitors overdose through **cholinergic crisis**, because excessive acetylcholine accumulates at neuromuscular junctions which overstimulates receptors producing the effect; therefore, paralysis rather than normal muscle function results since prolonged depolarization inactivates sodium channels.

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