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← ScienceWhich process limits drug molecule penetration though gradients?
A)Transcellular active transport saturation✓
B)Intercellular lipophilicity driven exclusion
C)Paracellular tight junction blockage
D)Epithelial first pass metabolism
💡 Explanation
Active transport facilitates drug crossing; however, transport *saturation* limits high concentration gradients because the mechanism, *carrier-mediated transport*, reaches a maximum rate; therefore, the drug diffusion plateaus, rather than continually crossing a gradient.
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