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Which process limits drug molecule penetration though gradients?

A)Transcellular active transport saturation
B)Intercellular lipophilicity driven exclusion
C)Paracellular tight junction blockage
D)Epithelial first pass metabolism

💡 Explanation

Active transport facilitates drug crossing; however, transport *saturation* limits high concentration gradients because the mechanism, *carrier-mediated transport*, reaches a maximum rate; therefore, the drug diffusion plateaus, rather than continually crossing a gradient.

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