Which risk increases as acetaminophen dosage rises in the liver during a prolonged period?

💡 Explanation

Acetaminophen overdose leads to the formation of a toxic metabolite (NAPQI), which depletes glutathione stores. Because glutathione is essential for detoxification, saturation of the liver's detoxification pathways causes NAPQI to damage hepatocytes, therefore centrilobular necrosis occurs rather than glycogen synthesis, bile acid issues, or decreased fatty infiltration.

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