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Which risk increases when a bio-reactor substrate supply nears depletion?

A)Metabolic pathway flux destabilization
B)Product-complex precipitation increases
C)Enzyme-substrate lock saturation decreases
D)Maximum reaction Gibbs energy expansion

💡 Explanation

Pathway destabilization occurs because *reaction kinetics* now depend on transient limitations in substrates, therefore metabolic flux becomes chaotic, rather than a stable production rate seen with the usual substrate excess.

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