Which risk increases when disulfide bonds are disrupted in antibody-drug conjugates during circulation?

A)Premature drug release accelerating clearance✓

B)Increased aggregation altering biodistribution

C)Reduced target binding hindering efficacy

D)Elevated immunogenicity triggering immune response

💡 Explanation

When disulfide bonds break, payload release accelerates because these linkers maintain drug conjugation, causing premature detachment and quicker removal from circulation and tissue penetration. Therefore, premature drug release occurs, rather than aggregation, binding, or immunogenicity which involve alternative breakdown mechanisms acting on separate components.

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Which risk increases when disulfide bonds are disrupted in antibody-drug conjugates during circulation?

💡 Explanation

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