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Which risk increases when salt bridge integrity decreases in a protein?

A)Increased protein aggregation
B)Decreased enzymatic activity
C)Enhanced membrane permeability
D)Reduced cofactor binding

💡 Explanation

Increased protein aggregation occurs because disrupting salt bridges weakens electrostatic attraction, leading to improper folding via hydrophobic interactions. Therefore, proteins clump together because of unfolding, rather than maintaining structure or function under native conditions.

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