Why does a patient with chronic insulin resistance require increasingly higher insulin doses to manage their type 2 diabetes?

💡 Explanation

Chronic insulin resistance impairs the normal insulin-mediated GLUT4 translocation to the cell membrane in skeletal muscle and adipose tissue, therefore, glucose uptake is reduced, because cells become less responsive even with increased insulin. The other options are not the primary mechanisms of resistance, rather than compensatory or downstream effects.

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