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← Human Body & HealthWhy does administering high insulin doses fail to restore normal glucose uptake in Type 2 Diabetes despite sufficient insulin receptors?
A)Increased receptor internalization eliminates signaling
B)Autoantibodies block insulin receptor binding
C)Impaired GLUT4 translocation reduces glucose transport✓
D)Excessive glucagon overrides insulin signals
💡 Explanation
In Type 2 Diabetes, insulin resistance occurs because the downstream signaling pathway to GLUT4 is impaired, resulting in reduced GLUT4 translocation to the cell membrane despite insulin binding; therefore, glucose uptake remains low rather than receptor binding being directly blocked or glucagon overriding insulin's effects.
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