Why does allogeneic hematopoietic stem cell transplantation, following myeloablative conditioning, represent a curative treatment for patients with severe aplastic anemia?

💡 Explanation

Hematopoietic stem cell transplantation restores hematopoiesis because the donor cells replace the patient's damaged bone marrow, therefore overcoming the underlying aplastic anemia. Rather than increasing erythropoietin or influencing B12/iron levels directly, the transplant addresses the root cause.

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