Why does an ovarian follicle sometimes fail to release an oocyte despite high levels of luteinizing hormone (LH)?

💡 Explanation

Follicle rupture requires breakdown of the follicular wall; this is mediated by MMPs. Defective MMP activity prevents follicle rupture and oocyte release despite LH surge, because LH stimulates MMP production rather than directly causing rupture. Therefore, a defective MMP activity causes oocyte retention, rather than other hormonal imbalances.

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