Why does arterial stiffness exacerbate hypertension in individuals with chronic kidney disease?

💡 Explanation

Arterial stiffness reduces the buffering capacity of the arteries, which impairs baroreceptor function because the pulse pressure is higher and sensed less effectively. This blunts the normal feedback loop mediated partially by aldosterone, causing an overcorrection that further elevates blood pressure, therefore, impaired baroreceptor sensitivity exacerbates hypertension, rather than direct vasodilation.

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