Why does chronic hypertension, despite adequate arterial baroreceptor signaling, often necessitate multiple drug therapies including aldosterone antagonists?

💡 Explanation

The RAAS (renin-angiotensin-aldosterone system) contributes to sustained hypertension because aldosterone increases sodium and water retention, expanding blood volume and pressure, therefore RAAS inhibition is crucial in managing hypertension rather than relying solely on baroreceptor reflexes or vasodilation.

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