Why does chronic overstimulation of insulin receptors due to consistently high blood glucose eventually lead to insulin resistance in type 2 diabetes?

💡 Explanation

Overstimulation induces receptor downregulation through increased internalization and degradation via endocytosis. This is because the cell reduces its sensitivity to insulin to protect against overstimulation; therefore, insulin resistance occurs, rather than increased receptor affinity or enhanced exocytosis which would increase sensitivity.

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