Why does damaged skin sometimes develop keloid scars following wound closure, despite collagen synthesis?

💡 Explanation

Keloid formation arises from an imbalance in collagen remodeling. Excessive TGF-β1 signaling during wound healing stimulates fibroblasts to overproduce collagen, rather than organizing it properly; therefore, keloid scars form because this cytokine imbalance overwhelms normal regulatory processes, rather than simply a lack of growth factors.

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