Why does diffuse axonal injury from concussive events cause widespread neurological deficits in the brain, even if a CT scan shows no macroscopic lesions?

💡 Explanation

Diffuse axonal injury induces widespread damage because the rapid acceleration/deceleration causes axonal strain. This strain disrupts the transport of essential proteins and organelles along the axons, therefore causing widespread dysfunction, rather than localized macroscopic lesions observable on CT scans or direct neuronal death.

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