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Human Body & Health

Why does hyperthyroidism often cause insomnia, rather than fatigue, despite increased metabolic demand?

A)Increased cortisol receptor downregulation occurs
B)Thyroid hormones directly enhance adrenergic signaling
C)Melatonin synthesis pathways become suppressed
D)Negative feedback on TRH intensifies

💡 Explanation

Hyperthyroidism enhances adrenergic signaling because thyroid hormones increase the sensitivity and number of adrenergic receptors in the brain, leading to increased alertness and arousal. Therefore, insomnia results rather than fatigue, rather than direct metabolic exhaustion from energy use.

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