Why does hypertrophic scarring, characterized by excessive collagen deposition during wound healing, occur more frequently in individuals with darker skin complexions?

💡 Explanation

Hypertrophic scarring is linked to elevated levels of transforming growth factor beta 1 (TGF-β1). This is because increased TGF-β1 signaling promotes excessive collagen synthesis by fibroblasts, leading to disorganized deposition. Therefore, individuals with darker skin are predisposed to this outcome, rather than decreased growth factors or enhanced metalloproteinase activity.

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