Why does increased mast cell activity cause bronchospasm during an asthma attack?

💡 Explanation

Bronchospasm in asthma occurs because mast cells release histamine and leukotrienes, potent bronchoconstrictors that act directly on the airway smooth muscle, therefore, causing the airways to narrow, rather than increased CO2, epinephrine, or IgG antibodies causing this effect.

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