Why does late luteal phase support of the endometrium fail during cycles without fertilization?

💡 Explanation

In the absence of fertilization, the corpus luteum undergoes luteolysis, which means it stops producing progesterone; because progesterone supports the endometrium, its decline causes endometrial shedding. Therefore, the endometrium support fails due to progesterone loss, rather than sustained hormone activity from other factors.

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