Why does neuronal function decline during neurodegenerative diseases featuring protein aggregates like amyloid plaques or Lewy bodies?

💡 Explanation

Neuronal function declines because impaired protein clearance mechanisms, such as autophagy and proteasomal degradation, lead to the accumulation of toxic protein aggregates. Therefore, cellular processes are disrupted, rather than enhanced mitochondrial function or neurogenesis compensating for the damage.

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