Why does peripheral artery disease (PAD) cause leg pain during exercise, which is relieved by rest?

💡 Explanation

PAD causes leg pain during exercise due to ischemia because atherosclerotic plaques narrow the arteries, restricting blood flow to the muscles. Consequently, oxygen supply is insufficient during exertion, leading to pain. Therefore, rest relieves the pain, rather than increased oxygen supply or improved venous return.

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