Why does prolonged exposure to synthetic progestins increase osteoporosis risk in postmenopausal women?

💡 Explanation

Synthetic progestins can suppress the hypothalamic-pituitary-ovarian axis, leading to decreased estrogen production; because bone health depends on estrogen's maintenance of bone density, its reduction accelerates bone resorption. Therefore, osteoporosis risk increases, rather than direct receptor interactions or calcium blockage being the primary driver.

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