Why does sepsis cause widespread organ damage in the human body, despite antibiotics targeting the initial bacterial infection?

💡 Explanation

Sepsis leads to organ damage due to a cytokine storm, wherein the immune system's excessive release of cytokines causes systemic inflammation and tissue damage, because the immune response spirals out of control. Therefore, the organ damage stems from the immune response rather than the infection itself, rather than direct bacterial toxin effects.

• Why does the luteal phase exhibit relatively stable progesterone levels, rather than precipitous drops as follicles degrade?
• If an athlete restricts water intake before prolonged exercise, why does plasma osmolality increase despite vasopressin release affecting the collecting ducts?
• Why does glossitis occur in pellagra sufferers more readily than in individuals with sufficient niacin intake?
• Which risk escalates when interstitial lung distance increases?
• An astronaut experiences prolonged microgravity; which effect dominates on returning to Earth due to thermoregulation and cardiovascular system interaction?
• Why does continued stimulant abuse escalate compulsive drug-seeking behavior related to the nucleus accumbens?