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← Human Body & HealthWhy does severe angioedema, characterized by rapid swelling, potentially cause airway obstruction during anaphylaxis?
A)Increased interleukin-6 desensitizes pain receptors
B)Epinephrine directly constricts bronchial smooth muscle
C)Complement cascade causes vasodilation
D)Histamine increases vascular permeability in mucosa✓
💡 Explanation
Histamine release from mast cells during anaphylaxis causes increased vascular permeability within the laryngeal mucosa, because this mechanism results in fluid extravasation and rapid tissue swelling. Therefore, airway obstruction occurs, rather than vasodilation caused by the complement cascade or direct bronchodilation by epinephrine.
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