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Human Body & Health

Why does the nervous system often struggle to distinguish between chronic pain and acute pain following peripheral nerve sensitization?

A)Increased glial cell inhibition
B)Decreased neurotransmitter reuptake efficacy
C)Central sensitization of pain pathways
D)Reduced dorsal horn interneuron activation

💡 Explanation

Central sensitization explains the overlap in processing because it involves long-lasting increases in the excitability of neurons in the spinal cord following peripheral nerve sensitization. This results in the brain perceiving chronic and acute pain similarly; therefore, option C is correct, rather than other options that do not involve widespread neural changes.

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