Why does transdermal drug delivery exhibit variable efficacy between individuals related to skin barrier function?

💡 Explanation

Transdermal drug delivery is affected by skin permeability, which varies among individuals because the intercellular lipid lamellae composition and organization in the stratum corneum influences the diffusion pathway. Therefore, polymorphism in these lipids affect drug absorption, rather than factors primarily impacting nutrient transport or sweat excretion.

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