A patient exhibits tremors and rigidity characteristic of Parkinson's disease. What process fails to prevent cellular dysfunction when alpha-synuclein aggregates accumulate in dopaminergic neurons?

💡 Explanation

Parkinson's disease involves the accumulation of alpha-synuclein aggregates, leading to cellular dysfunction. Impaired proteasomal protein degradation prevents the removal of these toxic aggregates, because the proteasome is crucial for degrading misfolded proteins. Therefore, the dysfunction arises from the aggregates persisting, rather than other cellular processes being directly compromised.

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