A patient's cells exhibit normal hormone receptor levels, but fail to respond to increased insulin. Why does the insulin signaling cascade fail?

💡 Explanation

Intracellular signal transduction relies on downstream proteins activating one another. If those proteins are impaired, the receptor can bind but the signal never reaches its target, because the cascade is broken, therefore the cellular response is absent, rather than due to receptor abnormalities or hormone-related factors.

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