A patient's neurons show increased levels of insoluble protein aggregates. If intracellular proteasomal degradation is impaired, which consequence follows?

💡 Explanation

If proteasomal degradation is impaired, then aggregate clearance via autophagy declines because the cell relies more heavily on autophagy to remove the aggregates. Therefore, autophagic flux decreases, rather than other compensatory cellular processes compensating for the proteasomal dysfunction.

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