A patient's skin graft fails to vascularize, leading to necrosis. Which mechanism explains why skin grafting outcome requires functional angiogenesis?

💡 Explanation

Angiogenesis—new blood vessel formation—is essential for skin graft survival because it provides nutrients and oxygen to the grafted tissue, preventing necrosis. Without functional angiogenesis, hypoxia occurs, therefore the graft fails. Rather than melanin, keratinocytes, or sebum being directly involved in initial graft survival.

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