A patient with a thyroid tumor begins producing excessive T4. Which downstream effect is MOST likely to occur due to negative feedback?

💡 Explanation

Increased T4 from the tumor triggers negative feedback, inhibiting TSH release from the pituitary gland. Because TSH stimulates thyroid hormone production, its suppression reduces further hormone synthesis; therefore, TSH decreases, rather than increasing, and iodine uptake would not be elevated.

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